NFL PrizePicks Player Predictions for Chiefs vs. Jaguars MNF (10/6)

Mahomes of the Chiefs

Week 5, Monday Night Football: Below are three of the best picks on PrizePicks according to our projections team for the Chiefs vs. Jaguars game on October 6, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.

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Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.

Below, I’ll detail how I’m approaching things on PrizePicks for Chiefs vs. Jaguars.

First… Sign Up to Make NFL PrizePicks Picks

If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo codeGRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.

When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!

PrizePicks Top NFL Picks for Chiefs vs. Jaguars

Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Monday Night Football:

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Chiefs vs. Jaguars NFL PrizePicks Predictions

Patrick Mahomes more than 23.5 Passing Completions

The passing completions projection for Patrick Mahomes looks like a strong pick based on the current data. The PrizePicks projection of 23.5 compares favorably based on our NFL simulations. This pick projects to hit 57.5% of the time based on the assumptions, and that represents a 3.2% edge.

Xavier Worthy more than 4.5 Receptions

The receptions projection for Xavier Worthy looks like a strong pick based on the current data. The PrizePicks projection of 4.5 compares favorably based on our NFL simulations. This pick projects to hit 57.3% of the time based on the assumptions, and that represents a 3.0% edge.

Parker Washington more than 15.5 Receiving Yards

The receiving yards projection for Parker Washington looks like a strong pick based on the current data. The PrizePicks projection of 15.5 compares favorably based on our NFL simulations. This pick projects to hit 56.4% of the time based on the assumptions, and that represents a 2.0% edge.

Editor’s Note: Looking for more places to play? Check out our Underdog promo code and PrizePicks promo code.

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About the Author

meansy53
Andy Means (meansy53)

Andy Means (aka meansy53) was a walk-on with the esteemed Duke University basketball team for 3 years before graduating in 2004. He also has a Master’s in Accounting from the Indiana University Kelley School of Business and has been playing DFS since 2014 (qualifying for multiple Live Finals). In the summer of 2022, Andy took over the role of Premium Content Director for the RotoGrinders Network, overseeing the vast array of content that is created on RotoGrinders, ScoresAndOdds, and FantasyLabs. Follow Andy on X – @ameansy
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