CFB DFS DraftKings Main Slate Breakdown: Week 10

by Jordan Vanek (vanekjordan)

Created Nov 6, 2026

Last Updated 2026-11-06 16:53:51 Premium Content Part of the product CFB Premium

Using his experience as a former scout and staff member at Central Florida under Josh Heupel, Jordan Vanek takes an in-depth look at the upcoming CFB DFS main slate on DraftKings for Week 10. Winner of the Fantasy Sports Writers Association’s 2025 College Sports Writer of the Year award, Jordan’s deep dive into the best stacks, running backs, and wide receivers is a must-read before you start building your lineups.

This weekend features one of the best slate of games we’ve had in college football all season. The Holy War kicks things off at 12:00 PM ET, with two top-10 teams battling for a possible top-3 spot on the College Football Playoff. Texas travels to Missouri in a matchup where both teams could either strengthen their playoff chances or put themselves in serious danger. UCLA heads to Minnesota to face a team that has already pulled off a few upsets and given several others a scare.

Alabama at LSU should have massive CFP implications. With the committee ranking Alabama 5th, I think that tells us a lot about how they view Alabama, and it’s more about LSU proving they should be in there. Then there’s Oregon at Ohio State, where Ohio State could be in real danger of missing this year’s CFP if they can’t figure things out without Julian Sayin.

And that’s just the main slate. The night games still feature Kentucky at Tennessee, Miami at Notre Dame, Georgia at Ole Miss, and West Virginia at Texas Tech. There are CFP implications everywhere you look, and we should be in for an incredible day of college football.

The funny thing is that, from a DFS perspective, most of these games don’t feature the popular plays we’re building our lineups around. That means we can actually sit back and enjoy some incredible football without having to root for our guys or sweat every big play from someone we don’t have in our lineups. Sometimes it’s nice to just watch football, and this weekend gives us plenty of opportunities to do exactly that.

As always, our CFB DFS projections will be updated throughout Saturday’s slate with any news that comes out. Our projections team will also be posting real-time updates in the RotoGrinders Discord, letting you know what news came in and how it impacted the projections.

CFB DFS DraftKings Picks: Top Stacks, RBs, & WRs for Week 10

Before getting into this graph, Florida State fired its head coach and defensive coordinator, promoting Ernie Sims to DC. Sims previously took over as interim DC at USF, where his blitz rate never exceeded 30% in 3 games after the defense had blitzed 40% of the time through 5 games. He also shifted away from man coverage after one unsuccessful attempt to use it heavily. Based on those changes, I expect Florida State to blitz less and play more zone coverage, which is the opposite of what this graph suggests.

Any team playing man coverage on more than 25% of snaps is above the national average, so Clemson and Utah are in a category that very few teams reach. Washington, UCLA, Texas A&M, and Kansas State also play man coverage at high rates. On the other side, plenty of teams lean heavily on zone coverage, including Houston, Alabama, Cincinnati, and LSU. South Carolina has also been playing a lot more zone coverage recently.

How teams approach zone and man coverage can be very different. For example, Alabama lives in Cover 3 concepts, while Houston and Cincinnati play a lot more two-high shells. Syracuse runs a coverage scheme that could confuse Tait Reynolds, but they’ve also allowed plenty of big plays through the air over the last month.

Missouri, Utah, Texas A&M, Washington, and UCLA are teams that love single-high coverage, with Utah in particular leaning heavily on Cover 1 and bringing pressure. If you have a wide receiver who can consistently win his individual matchup, you can get performances like Amare Thomas’ 133 yards or Cam Pickett’s 134 yards. The big-play opportunities are there, but the receiver has to win his matchup and the QB has to deliver an accurate ball.

Game Stacks

Blake Barnett ($4,500, QB, Kansas State)

Josh Manning ($4,900, WR, Kansas State)

Derrick Salley Jr. ($3,700, WR, Kansas State)

Caleb Hawkins ($9,500, RB, Oklahoma State)

Barnett made his first start last weekend on the road, and his usage was exactly what you want to see from a QB for DFS. He threw the ball 28 times for 3 touchdowns while adding 11 designed runs and 4 scrambles. This weekend, he’s minimum-priced and facing an Oklahoma State defense that has been horrible against the QBs over the last 5 weeks. They’ve allowed over 20 DK points in every game during that stretch, with QBs beating them through the air and on the ground. Some of those performances have even come from below-average QBs. For Barnett, there are three WRs worth noting: Manning, Salley, and Jaron Tibbs ($5,400). I’m highlighting Manning and Salley because of their roles in the offense. Tibbs has moved into the slot, and most of the receiving production against Oklahoma State this season has come from outside WRs.

Jamal Polite had 171 yards, with none of that production coming from the slot. Joseph Williams and DeAndre Moore Jr. both went over 120 yards, with less than 15% of their production coming from the slot. The only slot WR to surpass 100 yards was Amare Thomas, who is stylistically completely different from Tibbs. Tibbs is a big-bodied slot WR, and there’s simply nothing in this matchup that I can point to as a reason to expect that role to succeed. That’s why I prefer Manning and Salley as the stacking options with Barnett.

The main bring-back is Hawkins, and I’ll include the WR graph against single-high coverage below if you want to pair him with Wyatt Young ($7,800), Justin Bowick ($7,500), or Miles Coleman ($3,900). Hawkins is averaging 194 yards from scrimmage over the last month, including 78 receiving yards per game. He has a legitimate shot at hitting the double bonus, scoring multiple touchdowns, and completely dominating this matchup.

If you’re looking to fully stack this game, Bowick and Coleman are my preferred WR options. Young is great too, but the salary difference between Young and Coleman is significant. Kansas State’s one game allowing a WR to surpass 100 yards came against Reed Harris, which tells me they can struggle with elite athleticism and size. That fits Bowick’s profile more than the others.

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