CFB DFS DraftKings Main Slate Breakdown: Week 10

by Jordan Vanek (vanekjordan) Last Updated 2025-10-31 18:44:03 Premium Content Part of the product CFB Premium

Using his experience as a former scout and staff member at Central Florida under Josh Heupel, Jordan Vanek takes an in-depth look at the upcoming CFB DFS main slate on DraftKings for Week 10. Formerly of The 33rd Team and 4for4 Fantasy Football, Jordan’s deep dive into the best stacks, running backs, and wide receivers is a must-read before you start building your lineups.

This is the weakest quarterback slate of the season, which actually makes it a great one for stacking. Most of the QBs on this slate will need help to put up big scores – there’s no one projecting over 25 points, and there are no dominant rushing threats. That creates a perfect setup to find the best passing options and build around them. Two quarterbacks stand out well above the rest for me, and that’s where my lineups will start.

Injuries always pop up, which is why our CFB DFS projections are so valuable for identifying who benefits when someone gets ruled out. They’ll be updated constantly on Saturday as news breaks, giving you a clear read on ownership trends and lineup edges. Our projections team will also be posting real-time updates in the RotoGrinders Discord, so make sure you’re in there throughout the day.

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CFB DFS DraftKings Picks: Top Stacks, RBs, & WRs for Week 10

Several teams on this list have played man coverage at a much higher rate than most programs in the country. Boston College, in particular, stands out – and there’s one specific wide receiver I’ll touch on later who can really take advantage of that. Notre Dame also relies heavily on man coverage, but when fully healthy, they boast some of the best cover corners in the nation and have been playing much better defensively in recent weeks.

On the other end of the spectrum, Indiana and Virginia Tech run zone-based schemes. There’s one Louisville receiver who stands out well above the rest against zone coverage, and he’s my preferred option if you’re targeting that offense.

Florida’s run defense is beatable largely because they live in two-high coverage. It’s tough to throw on them due to how often they use that look and how it forces offenses to run the ball. The key to beating Quarters coverage is getting the ball into space and creating yards after the catch. When four defenders are covering deep and four are rushing the quarterback, that leaves only three to patrol the middle – an area where low-aDOT, high-YAC receivers can thrive. The other way to exploit it is with pure speed – receivers fast enough to blow past deep defenders who bite on the run.

There are also several heavy single-high teams on the slate. It’ll be interesting to see whether Clemson can defend Duke’s go-to single-high coverage beater, and I think SMU would be wise to load the box against Miami and force Carson Beck to win over the top.

Game Stacks

Carson Beck ($6,700, QB, Miami)

Malachi Toney ($5,900, WR, Miami)

CJ Daniels ($5,100, WR, Miami)

Chris Johnson Jr. ($4,300, RB, SMU) or Romello Brinson ($4,800, WR, SMU)

SMU is the only team on the slate that’s allowed over 2,100 passing yards, and opponents haven’t been able to run the ball effectively against them. I expect SMU to sell out against the run and force Beck to beat them through the air – his turnovers are their best path to pulling an upset.

Beck should see plenty of single-high coverage, and his offense really funnels through two primary targets: Toney and Daniels. Toney is one of the top playmakers in the country, while Daniels has emerged as the red-zone weapon – scoring 6 of Beck’s 12 passing touchdowns this season. To maximize Beck’s upside, you’ll want two of his pass-catchers in your builds.

SMU has allowed 7 wide receivers to top 20 DK points this season, including 3 wide receivers from Baylor (an offense similar to Miami’s). Toney should handle the yardage while Daniels provides the scoring upside, and players like Joshua Moore ($3,200, WR) and Keelan Marion ($3,100, WR) can help push Beck toward that 300-yard bonus.

I’m not going to force a bring-back in this stack, but there are two players who could definitely pay off in this matchup. When Miami faced Louisville, it was outside zone and speed that exposed their run defense. They’re dominant up front but vulnerable on the perimeter, and former Miami RB Chris Johnson Jr. – one of the fastest players in college football – has the explosiveness to break multiple big runs.

As for Brinson, his advantage lies over the middle of the field. I don’t expect SMU to hit many deep shots, but I do think they can attack Miami between the hashes, which suits Brinson’s skill set perfectly. He’s also a former Hurricane, now playing under ex-Miami offensive coordinator Rhett Lashlee – adding a little extra motivation to the matchup.

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