CFB DFS DraftKings Main Slate Breakdown: Week 6

by Jordan Vanek (vanekjordan) Last Updated 2025-10-04 13:37:51 Premium Content Part of the product CFB Premium

Using his experience as a former scout and staff member at Central Florida under Josh Heupel, Jordan Vanek takes an in-depth look at the upcoming CFB DFS main slate on DraftKings for Week 6. Formerly of The 33rd Team and 4for4 Fantasy Football, Jordan’s deep dive into the best stacks, running backs, and wide receivers is a must-read before you start building your lineups.

Emmanuel Henderson putting up over 200 receiving yards was great for my best ball teams, but it crushed my DFS builds with Brendan Sorsby, Cyrus Allen, and LeShon Williams. Sometimes when an RB goes down, it doesn’t mean the next guy in line gets a dominant workload; it can actually shift the offense toward more passing opportunities. That’s an easy but important DFS lesson.

This weekend, we don’t have the “hurt RB” scenario, but we do have several fantastic cheap WR options. One of my favorites is going very overlooked because of an unreported camp injury. Honestly, this might be my favorite slate of the year for cheap WRs, as the value is strong, and many of these players aren’t drawing much attention.

To keep tabs on who’s popular, check out our CFB DFS projections. They’ll be updated constantly on Saturday as news breaks, giving you the best read on ownership and lineup edges. With a few key injuries to watch (like Baylor RB Bryson Washington), this is also a slate where late-swap opportunities could make a huge difference.

CFB DFS DraftKings Picks: Top Stacks, RBs, & WRs for Week 6

Cincinnati’s zone coverage was shredded last weekend by Kansas, and this week, there’s a particular cheap option I really like. Alabama leans heavily on zone, and it makes sense against Vanderbilt since zone coverage keeps defenders’ eyes on the QB, which is important for containing Pavia’s scrambling ability. Meanwhile, Oklahoma State just fired its defensive coordinator, so it’ll be worth watching if they shift to more zone looks this weekend. That kind of change can often create a slower start for the opposing passing game. Beyond those points, there isn’t a ton to take away from these matchups.

If you’re wondering why Miami was able to take the soul out of Florida’s defense, a lot of it comes down to how often they run two-high shells. If Texas can establish the run, they’ll find success against that look, but based on what we’ve seen this season, I’m not convinced they can. Illinois continues to get gashed through the air, yet they stick with single-high coverage to stop the run, trusting their secondary even when it backfires. As for Cincinnati, they lean heavily on Cover 3, but their boundary corners simply don’t have the speed to keep up.

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