MLB PrizePicks Player Predictions for Thursday (6/5)

Mikolas of the Cardinals

Thursday, June 5, 2025: Below are three of the best picks for today’s MLB slate on PrizePicks according to our projections team. Using factors like Statcast data, advanced sabermetrics, weather impacts, and environmental factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.

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Don’t forget to check out our MLB weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks as the day progresses. And you can always stay up to date on exactly what a team’s lineup is by heading to our MLB starting lineups page.

Below, I’ll detail how I’m approaching things on PrizePicks for this Thursday slate.

First… Sign Up to Make MLB PrizePicks Picks

If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for MLB matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.

When making your PrizePicks picks today, let RotoGrinders do the heavy lifting for you!

PrizePicks Top MLB Picks for June 5, 2025

Now that you’re signed up, here are some of our top MLB DFS picks on PrizePicks for Thursday:

Send these picks directly to your entry!PLACE THIS ONPRIZEPICKS

Royals vs. Cardinals MLB PrizePicks Predictions

Miles Mikolas less than 21.5 Fantasy Score

The Fantasy Score projection for Miles Mikolas looks like a strong pick based on the current data. The PrizePicks projection of 21.5 compares favorably based on our MLB simulations. This pick projects to hit 58.7% of the time based on the assumptions, and that represents a 4.4% edge.

Rangers vs. Rays MLB PrizePicks Predictions

Jack Leiter more than 15.5 Outs

The outs projection for Jack Leiter looks like a strong pick based on the current data. The PrizePicks projection of 15.5 compares favorably based on our MLB simulations. This pick projects to hit 56.9% of the time based on the assumptions, and that represents a 2.6% edge.

Diamondbacks vs. Braves MLB PrizePicks Predictions

Brandon Pfaadt more than 5.5 Hits Allowed

The hits allowed projection for Brandon Pfaadt looks like a strong pick based on the current data. The PrizePicks projection of 5.5 compares favorably based on our MLB simulations. This pick projects to hit 57.9% of the time based on the assumptions, and that represents a 3.5% edge.

Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.

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About the Author

Jbails26
Justin Bailey (Jbails26)

Justin Bailey (aka jbails26) is the Lead Editor for RotoGrinders and FantasyLabs. He’s been playing DFS since 2013 and specializes in small-field NFL and PGA contests (but still dabbles in MME). Justin qualified for the DraftKings Fantasy Golf World Championship in 2023. Follow Justin on Twitter – @justinbailey32