MLB PrizePicks Player Predictions for Tuesday (9/16)
Tuesday, September 16, 2025: Below are three of the best picks for today’s MLB slate on PrizePicks according to our projections team. Using factors like Statcast data, advanced sabermetrics, weather impacts, and environmental factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our MLB weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks as the day progresses. And you can always stay up to date on exactly what a team’s lineup is by heading to our MLB starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for this Tuesday slate.
First… Sign Up to Make MLB PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for MLB matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your MLB PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top MLB Picks for September 16, 2025
Now that you’re signed up, here are some of our top MLB DFS picks on PrizePicks for Tuesday:
- Michael McGreevy less than 28.5 Fantasy Score
- Zebby Matthews less than 25.5 Fantasy Score
- Cam Schlittler more than 4.5 Hits Allowed
PRIZEPICKSReds vs. Cardinals MLB PrizePicks Predictions
Michael McGreevy less than 28.5 Fantasy Score
The fantasy score projection for Michael McGreevy looks like a strong pick based on the current data. The PrizePicks projection of 28.5 compares favorably based on our MLB simulations. This pick projects to hit 60.8% of the time based on the assumptions, and that represents a 6.4% edge.
Yankees vs. Twins MLB PrizePicks Predictions
Zebby Matthews less than 25.5 Fantasy Score
The fantasy score projection for Zebby Matthews looks like a strong pick based on the current data. The PrizePicks projection of 25.5 compares favorably based on our MLB simulations. This pick projects to hit 57.5% of the time based on the assumptions, and that represents a 3.1% edge.
Cam Schlittler more than 4.5 Hits Allowed
The hits allowed projection for Cam Schlittler looks like a strong pick based on the current data. The PrizePicks projection of 4.5 compares favorably based on our MLB simulations. This pick projects to hit 58.1% of the time based on the assumptions, and that represents a 3.7% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
Image Credit: Imagn