| Brock McGinn | ANA | LW | Questionable | 2024-11-18 | Lower Body | McGinn is dealing with a lower body injury and is uncertain to take the ice for the Ducks. |
| Urho Vaakanainen | ANA | D | Questionable | 2024-11-13 | Upper Body | Vaakanainen is dealing with an upper-body injury and is uncertain to take the ice for the Ducks. |
| Robby Fabbri | ANA | LW | Out | 2024-11-12 | Undisclosed | Fabbri is dealing with an undisclosed injury and has been placed on the injured reserve list. |
| Mason McTavish | ANA | C | Out | 2024-11-09 | Upper Body | McTavish has been placed on the injured reserve list with an upper-body injury. |
| Cam Fowler | ANA | D | Out | 2024-11-08 | Upper Body | Fowler is dealing with upper body injury and has been placed on the injured reserve list. |
| Anthony Mantha | CGY | RW | Out | 2024-11-05 | Knee | Mantha is set to undergo surgery on his ACL and has been placed on the long-term injured reserve list. He will miss the remainder of the 2024-25 season. |
| Petr Mrazek | CHI | G | Out | 2024-11-19 | Personal | Mrazek is dealing with a personal matter and will not take the ice for the Blackhawks. |
| Seth Jones | CHI | D | Out | 2024-11-16 | Foot | Jones is dealing with a foot injury and has been placed on the short-term injured reserve list. |
| Laurent Brossoit | CHI | G | Out | 2024-09-20 | Knee | Brossoit is dealing with a knee injury and has been placed on the injured reserve list. |
| Darnell Nurse | EDM | D | Out | 2024-11-16 | Upper Body | Nurse is dealing with an upper body injury and will not take the ice for the Oilers. He is expected to miss at least 5-10 days. |
| Viktor Arvidsson | EDM | RW | Questionable | 2024-11-13 | Undisclosed | Arvidsson is dealing with an undisclosed injury and is uncertain to take the ice for the Oilers. |
| Evander Kane | EDM | LW | Out | 2024-09-20 | Hernia | Kane is dealing with a sports hernia and has been placed on the long-term injured reserve list. |
| Jesper Boqvist | FLA | C | Questionable | 2024-11-18 | Undisclosed | Boqvist is dealing with an undisclosed injury and is uncertain to take the ice for the Panthers. |
| Joel Eriksson Ek | MIN | C | Questionable | 2024-11-14 | Lower Body | Eriksson Ek is dealing with a lower-body injury and is uncertain to take the ice for the Wild. |
| Mats Zuccarello | MIN | RW | Out | 2024-11-14 | Lower Body | Zuccarello is dealing with a lower body injury and has been placed on the injured reserve list. He will miss at least 3-4 weeks. |
| Jonas Brodin | MIN | D | Questionable | 2024-11-10 | Upper Body | Brodin is batting an upper body issue and is uncertain to take the ice for the Wild. |
| Troy Grosenick | MIN | G | Out | 2024-10-02 | Knee | Grosenick is recovering from a torn ACL and will miss the entire 2024-25 season. |
| Mike Reilly | NYI | D | Out | 2024-11-18 | Heart | Reilly will undergo heart surgery and has been placed on the long-term injured reserve list. He will be out indefinitely. |
| Alexander Romanov | NYI | D | Questionable | 2024-11-02 | Upper Body | Romanov is dealing with an upper-body injury and is uncertain to take the ice for the Islanders. |
| Mathew Barzal | NYI | C | Out | 2024-11-01 | Upper Body | Barzal is dealing with an upper-body injury and has been placed on the long-term injured reserve list. He is expected to miss 4-6 weeks. |
| Adam Pelech | NYI | D | Out | 2024-11-01 | Face | Pelech is dealing with an injury to his face and has been placed on the injured reserve list. He is expected to miss 4-6 weeks. |
| Anthony Duclair | NYI | LW | Out | 2024-10-19 | Leg | Duclair is dealing with a leg injury and has been placed on the long-term injured reserve list. He is expected to be out for 4-6 weeks. |
| Tristan Lennox | NYI | G | Out | 2024-10-08 | Undisclosed | Lennox is dealing with an undisclosed injury and has been placed on the non-roster injured list. |
| Daylan Kuefler | NYI | LW | Out | 2024-10-08 | Undisclosed | Kuefler is dealing with an undisclosed injury and has been placed on the non-roster injured list. |
| Filip Chytil | NYR | C | Out | 2024-11-14 | Upper Body | Chytil is dealing with an upper-body injury and will not take the ice for the Rangers. |
| Riley Nash | NYR | C | Out | 2024-10-04 | Lower Body | Nash is dealing with a lower-body injury and and has been placed on the non-roster injured reserve list. |
| Kris Letang | PIT | D | Questionable | 2024-11-15 | Illness | Letang is dealing with an illness and is uncertain to take the ice for the Penguins. |
| Blake Lizotte | PIT | C | Out | 2024-11-13 | Concussion | Lizotte is dealing with a concussion and has been placed on the injured reserve list. |
| Cody Glass | PIT | C | Out | 2024-11-07 | Upper Body | Glass is dealing with an upper-body injury and has been placed on the injured reserve list. |
| Kevin Hayes | PIT | RW | Out | 2024-11-05 | Undisclosed | Hayes is dealing with an undisclosed injury and will be added to the injured reserve list. |
| Pierre-Olivier Joseph | STL | D | Questionable | 2024-11-14 | Undisclosed | Joseph is dealing with an undisclosed injury and is uncertain to take the ice for the Blues. |
| Philip Broberg | STL | D | Out | 2024-11-02 | Lower Body | Broberg is dealing with a lower-body injury and will not take the ice for the Blues. He is expected to miss 4-6 weeks. |
| Nick Leddy | STL | D | Out | 2024-10-16 | Lower Body | Leddy is dealing with a lower-body injury and has been placed on the injured reserve list. |
| Torey Krug | STL | D | Out | 2024-09-03 | Ankle | Krug is recovering from left ankle surgery and has been placed on the long-term injured reserve list. He is expected to miss the entire 2024-25 season. |
| Brayden Point | TB | C | Questionable | 2024-11-03 | Lower Body | Point is dealing with a lower-body injury and is uncertain to take the ice for the Lightning. |
| Jack Finley | TB | C | Out | 2024-09-20 | Undisclosed | Finley is dealing with an undisclosed injury and has been placed on the injured non roster list. He is expected to miss three months. |
| J.T. Miller | VAN | C | Out | 2024-11-19 | Personal | Miller is dealing with a personal matter and will not take the ice for the Canucks. |
| Brock Boeser | VAN | RW | Out | 2024-11-07 | Upper Body | Boeser is dealing with an upper-body injury and will not take the ice for the Canucks. He is expected to remain out indefinitely. |
| Derek Forbort | VAN | D | Out | 2024-11-06 | Knee | Forbort is dealing with a knee injury and has been placed on the long-term injured reserve list and will not take the ice for the Canucks. |
| Thatcher Demko | VAN | G | Out | 2024-09-20 | Lower Body | Demko is dealing with a lower-body injury and has been placed on the non-roster injured reserve list. |
| Logan Stanley | WPG | D | Out | 2024-11-09 | Undisclosed | Stanley is dealing with an undisclosed injury and has been placed on the injured reserve list. |
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