Million Dollar Musings: MLB DFS Picks Today for Tuesday 4/21

by Dave Potts (CheeseIsGood) Last Updated 2026-04-21 16:57:27 Premium Content Part of the product MLB DFS

Whether you are looking for the top pitchers or the best stacks, Dave Potts (aka CheeseIsGood) has you covered with an extensive deep dive into his MLB DFS picks today. Cheese, one of the preeminent baseball minds in all of fantasy sports and a winner of a $1,000,000 1st-place prize on both DraftKings and FanDuel, is here to give you his musings on the April 21, 2026 MLB DFS slate.

Happy Tuesday! We finally get rid of the Dodgers in Coors Field – banishing them to San Francisco – while the Padres are the next team into the Mile High City. At first glance, with the salaries up on both sides of the Coors Field game, it does not look like any sort of must-play, but we’ll see what happens when we get to the bats. On the pitching side, there’s a pretty solid top tier, with at least five aces that I am interested in playing.

Tuesday Pitching: MLB DFS Picks on DraftKings and FanDuel

We have a couple of sizeable pricing discrepancies between the sites, but I’ll use the DK pricing to draw a line between the tiers, using $8,000 as the cutoff. We also have aces on both sides of the good luck / bad luck spectrum to start the season, which leaves some room for questions and disagreement within this top tier.

TOP TIER PITCHING

• Yoshinobu Yamamoto at Giants – 28.5% K, 8% BB, 2.44 ERA, 3.33 SIERA
• Jesus Luzardo at Cubs – 28.7% K, 7.2% BB, 4.36 ERA, 3.30 SIERA
• Shota Imanaga vs. Phillies – 22.8% K, 4.8% BB, 3.56 ERA, 4.07 SIERA
• Nolan McLean vs. Twins – 30.7% K, 8.7% BB, 2.13 ERA, 3.04 SIERA
• Kris Bubic vs. Orioles – 25.1% K, 8.7% BB, 2.78 ERA, 3.83 SIERA
• Luis Castillo vs. A’s – 21.5% K, 6.4% BB, 3.71 ERA, 4.06 SIERA

Yoshinobu Yamamoto is sitting with a 2.10 ERA this season and has posted a quality start in all 4 of his starts. His strikeouts are down fairly dramatically from last season, but at the same time, his SwStr% is at a career high, and everything under the hood looks normal. Basically, this is the issue with using a small sample size (like 4 starts) to judge a strikeout rate. He had 1 bad start (‘bad’ for strikeouts; still good in real life) where he struck out just 2 batters, but his other 3 starts were all at least a 25% K rate. To me, he looks like the exact same guy as the past 2 seasons, and that’s how I’m viewing him for now. The matchup with the Giants in San Francisco is about average. They aren’t a high-strikeout team, they have a few good power bats, but they also aren’t anything special. I would say that if salary doesn’t matter, Yamamoto is my SP1. He is the most-expensive pitcher on both sites, so let’s look through the rest of these options before deciding if that changes things.

Want to read more? Sign up for MLB Premium!

-

-

-