MLB DFS Top Stacks: Thursday, May 22nd
MLB DFS is complex, which is why it helps to have data-driven tools at your disposal. That’s where we come in.
With some help from our Top Stacks tool, we can narrow down some of the stacks that are worth targeting for the upcoming MLB DFS slate. Our Top Stacks tool is powered by our MLB player projections that are available in our MLB optimizer, LineupHQ.
Also, don’t forget to check out our MLB weather page and MLB starting lineups leading up to lock. The last thing you want to do is stack up some teams that may get their game postponed or roster players who aren’t in the confirmed lineup.
MLB DFS Picks: Top Stacks for Thursday, May 22nd
Opto% Stack
Braves at Trevor Williams
The Braves stand out as the premier MLB DFS stack, leading all teams in both optimal stack rate and overall stack rating in our current projections. They also rank 3rd in Value%, underscoring their strong combination of upside and affordability. While Trevor Williams is not an easy matchup for righties, his notable struggles against lefty power make the Braves’ lefty bats especially appealing.
The implied run total for the Braves is 4.66, which is the highest total on the slate. Their offensive ceiling, as indicated by their top stack metrics, positions them as a high-upside play. Despite potential high popularity among DFS players, they’re still a compelling stack; we’ll just need to differentiate our lineups elsewhere.
Looking for more MLB DFS analysis? Check out CheeseIsgood’s Million Dollar Musings for the most in-depth breakdown in the industry.
Opto% Stack
Mariners at Lance McCullers
The Seattle Mariners present a compelling MLB DFS stack against Lance McCullers Jr., who remains rusty after missing time due to injury. Our projections rank the Mariners 4th in optimal stack rate and fifth in stack rating, with an implied run total of 4.50 (3rd-highest on the slate). McCullers’ recent struggles—including a 7-run, 1-out implosion against Cincinnati —highlight his vulnerability, particularly with command issues (83 pitches for 4 innings in his last start ). His inability to consistently throw strikes this season increases the likelihood of early traffic on the bases and a potential bullpen meltdown.
Key Mariners hitters like Cal Raleigh and Rowdy Tellez offer targeted upside. While McCullers historically induced ground balls, his current form suggests diminished control, making the Mariners a high-ceiling stack for DFS players seeking volatility-driven upside. The combination of projections, McCullers’ struggles, and Seattle’s power threats creates a scenario ripe for offensive production.
Top Leverage Stacks
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