MLB PrizePicks Player Predictions for Monday (7/21)
Monday, July 21, 2025: Below are three of the best picks for today’s MLB slate on PrizePicks according to our projections team. Using factors like Statcast data, advanced sabermetrics, weather impacts, and environmental factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our MLB weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks as the day progresses. And you can always stay up to date on exactly what a team’s lineup is by heading to our MLB starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for this Monday slate.
First… Sign Up to Make MLB PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for MLB matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top MLB Picks for July 21, 2025
Now that you’re signed up, here are some of our top MLB DFS picks on PrizePicks for Monday:
- Jake Irvin less than 4.5 Pitcher Strikeouts
- Kodai Senga less than 5.5 Pitcher Strikeouts
- Jacob Lopez more than 26.5 Fantasy Score
PRIZEPICKSReds vs. Nationals MLB PrizePicks Predictions
Jake Irvin less than 4.5 Pitcher Strikeouts
The strikeouts projection for Jake Irvin looks like a strong pick based on the current data. The PrizePicks projection of 4.5 compares favorably based on our MLB simulations. This pick projects to hit 59.0% of the time based on the assumptions, and that represents a 4.7% edge.
Angels vs. Mets MLB PrizePicks Predictions
Kodai Senga less than 5.5 Pitcher Strikeouts
The pitcher strikeouts projection for Kodai Senga looks like a strong pick based on the current data. The PrizePicks projection of 5.5 compares favorably based on our MLB simulations. This pick projects to hit 57.7% of the time based on the assumptions, and that represents a 3.4% edge.
Athletics vs. Rangers MLB PrizePicks Predictions
Jacob Lopez more than 26.5 Fantasy Score
The fantasy score projection for Jacob Lopez looks like a strong pick based on the current data. The PrizePicks projection of 26.5 compares favorably based on our MLB simulations. This pick projects to hit 55.8% of the time based on the assumptions, and that represents a 1.5% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
Image Credit: Imagn