MLB PrizePicks Player Predictions for Wednesday (9/17)
Wednesday, September 17, 2025: Below are three of the best picks for today’s MLB slate on PrizePicks according to our projections team. Using factors like Statcast data, advanced sabermetrics, weather impacts, and environmental factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our MLB weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks as the day progresses. And you can always stay up to date on exactly what a team’s lineup is by heading to our MLB starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for this Wednesday slate.
First… Sign Up to Make MLB PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for MLB matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your MLB PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top MLB Picks for September 17, 2025
Now that you’re signed up, here are some of our top MLB DFS picks on PrizePicks for Wednesday:
- Blake Snell less than 7.5 Pitcher Strikeouts
- McCade Brown less than 3.5 Pitcher Strikeouts
- Chandler Simpson less than 7.5 Fantasy Score
PRIZEPICKSPhillies vs. Dodgers MLB PrizePicks Predictions
Blake Snell less than 7.5 Pitcher Strikeouts
The pitcher strikeouts projection for Blake Snell looks like a strong pick based on the current data. The PrizePicks projection of 7.5 compares favorably based on our MLB simulations. This pick projects to hit 61.4% of the time based on the assumptions, and that represents a 7.1% edge.
Marlins vs. Rockies MLB PrizePicks Predictions
McCade Brown less than 3.5 Pitcher Strikeouts
The pitcher strikeouts projection for McCade Brown looks like a strong pick based on the current data. The PrizePicks projection of 3.5 compares favorably based on our MLB simulations. This pick projects to hit 59.2% of the time based on the assumptions, and that represents a 4.8% edge.
Blue Jays vs. Rays MLB PrizePicks Predictions
Chandler Simpson less than 7.5 Fantasy Score
The fantasy score projection for Chandler Simpson looks like a strong pick based on the current data. The PrizePicks projection of 7.5 compares favorably based on our MLB simulations. This pick projects to hit 58.5% of the time based on the assumptions, and that represents a 4.1% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
Image Credit: Imagn