NBA PrizePicks Player Predictions for Tuesday (10/21)
Tuesday, October 21, 2025: Below are three of the best picks for today’s NBA slate on PrizePicks according to our projections team. Using factors like advanced analytics, minutes, matchups, and pace, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Keep in mind that the NBA news cycle can get crazy, so what is listed below may become a better/worse play depending on how news breaks. Be sure to keep close tabs on our NBA starting lineups page and NBA injury report to get a current snapshot of who is in/out and what a team’s rotation and depth chart looks like.
Below, I’ll detail how I’m approaching things on PrizePicks for this Tuesday slate.
First… Sign Up to Make NBA PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NBA matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NBA PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NBA Picks for October 21, 2025
Now that you’re signed up, here are some of our top NBA DFS picks on PrizePicks for Tuesday:
- Alex Caruso less than 6.0 Rebounds & Assists
- Amen Thompson less than 12.5 Rebounds & Assists
- Marcus Smart less than 8.5 Points
PRIZEPICKSRockets vs. Thunder NBA PrizePicks Predictions
Alex Caruso less than 6.0 Rebounds & Assists
The rebounds & assists projection for Alex Caruso looks like a strong pick based on the current data. The PrizePicks projection of 6.0 compares favorably based on our NBA simulations. This pick projects to hit 63.7% of the time based on the assumptions, and that represents a 9.3% edge.
Amen Thompson less than 12.5 Rebounds & Assists
The rebounds & assists projection for Amen Thompson looks like a strong pick based on the current data. The PrizePicks projection of 12.5 compares favorably based on our NBA simulations. This pick projects to hit 61.5% of the time based on the assumptions, and that represents a 7.2% edge.
Warriors vs. Lakers NBA PrizePicks Predictions
Marcus Smart less than 8.5 Points
The points projection for Marcus Smart looks like a strong pick based on the current data. The PrizePicks projection of 8.5 compares favorably based on our NBA simulations. This pick projects to hit 60.3% of the time based on the assumptions, and that represents a 5.9% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
Image Credit: Imagn