NFL PrizePicks: Cowboys vs. 49ers Player Predictions for Sunday Night Football

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After a tough Week 4, we’ve bounced back with some incredibly successful PrizePicks predictions throughout Week 5 capped off with a perfect card from the NFL International Series this morning between the Jaguars and Bills. Tonight’s Sunday Night Football matchup featuring the Cowboys vs. 49ers consists of two great defenses and some of the most prolific play makers in all of football, providing an exciting evening of DFS Pick’em plays to follow.

Each week, I’ll deliver my top NFL PrizePicks predictions for Thursday, Sunday, and Monday Night Football. Use the PrizePicks referral code GRINDERS to receive a $100 deposit match to prep you for the NFL season.

PrizePicks Plays: Cowboys vs. 49ers

Brandon Aiyuk – 61.5 Receiving Yards

The Cowboys play among the most man coverage in the NFL, and Brandon Aiyuk is the 49ers’ most productive option in that type of defense. The RotoGrinders projections have Aiyuk surpassing this mark by over 16 yards. He’s gone well over 100 yards in two of his three games this season, and despite what looks on paper like a difficult matchup, it’s actually a phenomenal position for Aiyuk due to his skill against the Cowboys’ specific defensive style.

Play: Aiyuk – More Than 61.5 Receiving Yards

Christian McCaffrey – 32.5 Receiving Yards

A common trend in tonight’s PrizePicks predictions, Christian McCaffrey also projects to surpass his receiving yard total significantly in the RotoGrinders player projections. Additionally, the play has a nearly 64% success rate in the RotoGrinders Fantasy Pick’em Tool for PrizePicks. McCaffrey has gone over this total in back-to-back games and received a whopping 8 targets last week. He’s even more involved in the offense without Elijah Mitchell, and the 49ers will have to ride him once again to get past the Cowboys’ stout defense.

Play: McCaffrey – 32.5 More Than Receiving Yards

CeeDee Lamb – 66.5 Receiving Yards

I expect the Cowboys to be playing from behind in this one, leaving a perfect game script for Lamb to rack up receiving yards in the second half. He completes the trifecta, as he also has a 10+ yard receiving number in the RotoGrinders projections compared to his DFS Pick’em number. He’s been scripted out of a couple of games this year, as the Cowboys have had huge leads, but that shouldn’t be the case against an incredibly tough 49ers team that has still allowed some big games to top receivers early this season.

Play: Lamb – More Than 66.5 Receiving Yards



Image Credit: Getty Images

About the Author

tjzwarych1
TJ Zwarych (tjzwarych1)

TJ Zwarych is a longtime RotoGrinders member and has been rising up the DFS rankings. He has been producing content for a long time, previously contributing to sites like Bleacher Report, and he is also the Editor-In-Chief of Agents Of Fandom. TJ has multiple 6-figure DFS wins in his career and most recently finished in 13th place at the 2022 FanDuel MLB Live Final. Follow TJ on Twitter – @TJ_Zwarych5