NFL PrizePicks Player Predictions for Chiefs vs. Chargers FNF (9/5)
Week 1, Friday Night Football: Below are three of the best picks on PrizePicks according to our projections team for the Chiefs vs. Chargers game on September 5, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for Chiefs vs. Chargers.
First… Sign Up to Make NFL PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NFL Picks for Chiefs vs. Chargers
Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Friday Night Football:
- Will Dissly less than 5.0 Fantasy Points
- Cameron Dicker less than 8.5 Fantasy Points
- Harrison Butker less than 8.5 Fantasy Points
PRIZEPICKSChiefs vs. Chargers NFL PrizePicks Predictions
Will Dissly less than 5.0 Fantasy Points
The fantasy points projection for Will Dissly looks like a strong pick based on the current data. The PrizePicks projection of 5.0 compares favorably based on our NFL simulations. This pick projects to hit 59.0% of the time based on the assumptions, and that represents a 4.6% edge.
Cameron Dicker less than 8.5 Fantasy Points
The fantasy points projection for Cameron Dicker looks like a strong pick based on the current data. The PrizePicks projection of 8.5 compares favorably based on our NFL simulations. This pick projects to hit 57.8% of the time based on the assumptions, and that represents a 3.5% edge.
Harrison Butker less than 8.5 Fantasy Points
The fantasy points projection for Harrison Butker looks like a strong pick based on the current data. The PrizePicks projection of 8.5 compares favorably based on our NFL simulations. This pick projects to hit 55.5% of the time based on the assumptions, and that represents a 1.2% edge.
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