NFL PrizePicks Player Predictions for Panthers vs. 49ers MNF (11/24)
Week 12, Monday Night Football: Below are three of the best picks on PrizePicks according to our projections team for the Panthers vs. 49ers game on November 24, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for Panthers vs. 49ers.
First… Sign Up to Make NFL PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NFL Picks for Panthers vs. 49ers
Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Monday Night Football:
- Luke Farrell less than 3.5 Receiving Yards
- George Kittle less than 60.5 Receiving Yards
- Tommy Tremble less than 10.5 Receiving Yards
PRIZEPICKSPanthers vs. 49ers NFL PrizePicks Predictions
Luke Farrell less than 3.5 Receiving Yards
The receiving yards projection for Luke Farrell looks like a strong pick based on the current data. The PrizePicks projection of 3.5 compares favorably based on our NFL simulations. This pick projects to hit 65.5% of the time based on the assumptions, and that represents an 11.1% edge.
George Kittle less than 60.5 Receiving Yards
The receiving yards projection for George Kittle looks like a strong pick based on the current data. The PrizePicks projection of 60.5 compares favorably based on our NFL simulations. This pick projects to hit 56.3% of the time based on the assumptions, and that represents a 2.0% edge.
Tommy Tremble less than 10.5 Receiving Yards
The receiving yards projection for Tommy Tremble looks like a strong pick based on the current data. The PrizePicks projection of 10.5 compares favorably based on our NFL simulations. This pick projects to hit 55.0% of the time based on the assumptions, and that represents a 0.6% edge.
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