NFL PrizePicks Player Predictions for Patriots vs. Bills (10/5)
Week 5, Sunday Night Football: Below are three of the best picks on PrizePicks according to our projections team for the Patriots vs. Bills game on October 5, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for Patriots vs. Bills.
First… Sign Up to Make NFL PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NFL Picks for Patriots vs. Bills
Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Sunday Night Football:
- Josh Allen more than 29.0 Passing Attempts
- Josh Allen more than 20.0 Passing Completions
- TreVeyon Henderson less than 26.5 Rushing Yards
PRIZEPICKSPatriots vs. Bills NFL PrizePicks Predictions
Josh Allen more than 29.0 Passing Attempts
The passing attempts projection for Josh Allen looks like a strong pick based on the current data. The PrizePicks projection of 29.0 compares favorably based on our NFL simulations. This pick projects to hit 59.0% of the time based on the assumptions, and that represents a 4.7% edge.
Josh Allen more than 20.0 Passing Completions
The passing completions projection for Josh Allen looks like a strong pick based on the current data. The PrizePicks projection of 20.0 compares favorably based on our NFL simulations. This pick projects to hit 55.0% of the time based on the assumptions, and that represents a 0.6% edge.
TreVeyon Henderson less than 26.5 Rushing Yards
The rushing yards projection for TreVeyon Henderson looks like a strong pick based on the current data. The PrizePicks projection of 26.5 compares favorably based on our simulations. This pick projects to hit 55.3% of the time based on the assumptions, and that represents a 0.9% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
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