NFL PrizePicks Player Predictions for 49ers vs. Rams TNF (10/2)
Week 5, Thursday Night Football: Below are three of the best picks on PrizePicks according to our projections team for the 49ers vs. Rams game on October 2, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for 49ers vs. Rams.
First… Sign Up to Make NFL PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NFL Picks for 49ers vs. Rams
Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Thursday Night Football:
- Demarcus Robinson more than 2.5 Receptions
- Christian McCaffrey less than 7.0 Receptions
- Joshua Karty less than 8.5 Kicking Points
PRIZEPICKS49ers vs. Rams NFL PrizePicks Predictions
Demarcus Robinson more than 2.5 Receptions
The receptions projection for Demarcus Robinson looks like a strong pick based on the current data. The PrizePicks projection of 2.5 compares favorably based on our NFL simulations. This pick projects to hit 59.5% of the time based on the assumptions, and that represents a 5.1% edge.
Christian McCaffrey less than 7.0 Receptions
The receptions projection for Christian McCaffrey looks like a strong pick based on the current data. The PrizePicks projection of 7.0 compares favorably based on our NFL simulations. This pick projects to hit 56.8% of the time based on the assumptions, and that represents a 2.4% edge.
Joshua Karty less than 8.5 Kicking Points
The kicking points projection for Joshua Karty looks like a strong pick based on the current data. The PrizePicks projection of 8.5 compares favorably based on our NFL simulations. This pick projects to hit 56.3% of the time based on the assumptions, and that represents a 1.9% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
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