NFL Sleeper Fantasy Player Predictions for 49ers vs. Colts MNF (12/22)
Week 16, Monday Night Football: Below are three of the best picks on Sleeper Fantasy according to our projections team for the 49ers vs. Colts game on December 22, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on Sleeper Fantasy for 49ers vs. Colts.
First… Sign Up to Make NFL Sleeper Fantasy Picks
If you want to play along but haven’t signed up yet, grab a special offer with our Sleeper Fantasy promo code “GRINDERS” to unlock a generous bonus. Sleeper Fantasy – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL Sleeper picks today, let RotoGrinders do the heavy lifting for you!
Sleeper Fantasy Top NFL Picks for 49ers vs. Colts
Now that you’re signed up, here are some of our top NFL DFS picks on Sleeper Fantasy for Monday Night Football:
- Alec Pierce more than 1.5 Receptions
- Demarcus Robinson less than 18.5 Receiving Yards
49ers vs. Colts NFL Sleeper Fantasy Predictions
Alec Pierce more than 1.5 Receptions
The receptions projection for Alec Pierce looks like a strong pick based on the current data. The Sleeper projection of 1.5 compares favorably based on our NFL simulations. This pick projects to hit 65.7% of the time based on the assumptions, and that represents a 3.2% edge.
Demarcus Robinson less than 18.5 Receiving Yards
The receiving yards projection for Demarcus Robinson looks like a strong pick based on the current data. The Sleeper projection of 18.5 compares favorably based on our NFL simulations. This pick projects to hit 56.5% of the time based on the assumptions, and that represents a 0.4% edge.
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