Million Dollar Musings: MLB DFS Picks Today for Monday 9/22

by Dave Potts (CheeseIsGood) Last Updated 2025-09-22 15:06:34 Premium Content Part of the product MLB DFS

Whether you are looking for the top pitchers or the best stacks, Dave Potts (aka CheeseIsGood) has you covered with an extensive deep dive into his MLB DFS picks. Cheese, one of the preeminent baseball minds in all of fantasy sports and a winner of a $1,000,000 1st-place prize on both DraftKings and FanDuel, is here to give you his musings on the upcoming MLB DFS slate.

Happy Monday! We have a very slow night in MLB with just 3 games on the schedule. While I typically only write for slates of 5+ games, we’re going to go ahead and break this one down since it’s the only slate we have tonight, and there are only a few games left in the season.

But since we have some extra time, I’ll toss this little nugget in here for the 3% of you that might find it interesting. If you’ve been reading the Musings for a long time, you might remember that back in 2016-2018, DFS was not allowed in my home state of Alabama. I live close enough to the Georgia border that I would drive to Columbus, GA, just about every day during baseball season to enter my lineups. I had a go-to coffeehouse that I traveled to on most days, called Fountain City Coffeehouse in Columbus. It is a glorious little place with great coffee and a diverse clientele of artsy types. There were always a bunch of portraits hanging on the walls, drawn of regulars to the coffeehouse. Fast forward to present day, I just finished reading a novel by Allen Levi called Theo of Golden. In the novel, the main character, Theo, moves to a town called ‘Golden’ and becomes a regular at a coffeehouse where he purchases portraits off the walls and gifts them back to the people featured in the drawings. When I read the book, it all just seemed so familiar, down to so many little details about the coffeehouse and the town around it. Well, what do you know? It turns out that Levi based ‘Golden’ on Columbus, GA, and got the idea for the book at Fountain City Coffeehouse while looking at those portraits. There are no random traveling DFS players in the novel, but I still thought that was an interesting enough tidbit to kick off this small Monday slate. And now, back to the originally scheduled program.

Thankfully, we have no MLB weather concerns tonight, so let’s dive in and see what we can make of this little slate.

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Monday Pitching: MLB DFS Picks on FanDuel & DraftKings

All 6 pitchers on this slate are worth a mention, and we can split them down the middle into these two tiers:

TOP TIER ACES

• Chris Sale vs. Nationals – 32.3% K, 6% BB, 2.35 ERA, 2.88 SIERA
• Freddy Peralta at Padres – 28.1% K, 9.4% BB, 2.65 ERA, 3.72 SIERA
• Nick Pivetta vs. Brewers – 26.6% K, 6.5% BB, 2.81 ERA, 3.63 SIERA

Freddy Peralta and Nick Pivetta are great pitchers who are both capable of posting big starts at any time. But they are still not Chris Sale. On top of the better skills for Sale, it’s also a far easier matchup, as Peralta and Pivetta face each other’s low strikeout lineups. While the Brewers and Padres have lineups averaging below a 20% K rate, the Nationals have the highest strikeout rate in the league against lefties, with a silly 7 batters in their projected lineup above a 25% K rate. Sale is going to be massive chalk, and if you want to play the ownership game, it’s certainly fine on a small slate like this. Adding in how dominant he’s looked recently in the matchup, I can’t make any case to fade Sale, and I’m not going to overthink it here with Sale.

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