NFL PrizePicks Player Predictions for Week 5
Week 5: Below are three of the best picks for this week’s NFL slate on PrizePicks according to our projections team. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks as the week progresses. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on PrizePicks for Week 5.
First… Sign Up to Make NFL PrizePicks Picks
If you want to play along but haven’t signed up yet, grab a special offer with our PrizePicks promo code “GRINDERS” to get $50 on a $5 entry! PrizePicks – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL PrizePicks picks today, let RotoGrinders do the heavy lifting for you!
PrizePicks Top NFL Picks for Week 5
Now that you’re signed up, here are some of our top NFL DFS picks on PrizePicks for Week 5:
- Cam Skattebo less than 65.5 Rushing Yards
- Derrick Henry more than 78.5 Rushing Yards
- David Montgomery less than 45.5 Rushing Yards

Giants vs. Saints NFL PrizePicks Predictions
Cam Skattebo less than 65.5 Rushing Yards
The rushing yards projection for Cam Skattebo looks like a strong pick based on the current data. The PrizePicks projection of 65.5 compares favorably based on our NFL simulations. This pick projects to hit 62.9% of the time based on the assumptions, and that represents an 8.5% edge.
Texans vs. Ravens NFL PrizePicks Predictions
Derrick Henry more than 78.5 Rushing Yards
The rushing yards projection for Derrick Henry looks like a strong pick based on the current data. The PrizePicks projection of 78.5 compares favorably based on our NFL simulations. This pick projects to hit 62.0% of the time based on the assumptions, and that represents a 7.7% edge.
Lions vs. Bengals NFL PrizePicks Predictions
David Montgomery less than 45.5 Rushing Yards
The rushing yards projection for David Montgomery looks like a strong pick based on the current data. The PrizePicks projection of 45.5 compares favorably based on our NFL simulations. This pick projects to hit 60.5% of the time based on the assumptions, and that represents a 6.2% edge.
Editor’s Note: Looking for more places to play? Check out our Underdog promo code and Sleeper promo code.
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