NFL Underdog Player Predictions for 49ers vs. Colts MNF (12/22)
Week 16, Monday Night Football: Below are three of the best picks on Underdog according to our projections team for the 49ers vs. Colts game on December 22, 2025. Using factors like advanced participation data, the latest efficiency analytics, historical trends, and advanced matchup factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our NFL weather page, which is curated by our Chief Meteorologist, Kevin Roth, to see how that may impact these picks. And you can always stay up to date on exactly what a team’s depth chart is looking like by heading to our NFL starting lineups page.
Below, I’ll detail how I’m approaching things on Underdog for 49ers vs. Colts.
First… Sign Up to Make NFL Underdog Picks
If you want to play along but haven’t signed up yet, grab a special offer with our Underdog promo code “GRINDERS” to unlock a generous bonus. Underdog – one of the most popular DFS pick’em sites – provides player projections for NFL matchups each week. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your NFL Underdog picks today, let RotoGrinders do the heavy lifting for you!
Underdog Top NFL Picks for 49ers vs. Colts
Now that you’re signed up, here are some of our top NFL DFS picks on Underdog for Monday Night Football:
- Alec Pierce higher than 2.5 Targets
- Christian McCaffrey higher than 17.65 Fantasy Score
- Jonathan Taylor higher than 18.35 Fantasy Score
49ers vs. Colts NFL Underdog Predictions
Alec Pierce higher than 2.5 Targets
The targets projection for Alec Pierce looks like a strong pick based on the current data. The Underdog projection of 2.5 compares favorably based on our NFL simulations. This pick projects to hit 64.1% of the time based on the assumptions, and that represents a 9.1% edge.
Christian McCaffrey higher than 17.65 Fantasy Score
The fantasy score projection for Christian McCaffrey looks like a strong pick based on the current data. The Underdog projection of 17.65 compares favorably based on our NFL simulations. This pick projects to hit 60.9% of the time based on the assumptions, and that represents a 3.1% edge.
Jonathan Taylor higher than 18.35 Fantasy Score
The fantasy score projection for Jonathan Taylor looks like a strong pick based on the current data. The Underdog projection of 18.35 compares favorably based on our NFL simulations. This pick projects to hit 59.7% of the time based on the assumptions, and that represents a 1.9% edge.
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